Assessment of the dietary amino acid profiles and the relative biomarkers for amino acid balance in the low-protein diets for broiler chickens

Wang, Bin; Zhang, Xiaodan; Liu, Yongfa; Gao, Mingkun; Wang, Mi; Wang, Yuan; Wang, Xinzhi; Guo, Yuming

doi:10.1186/s40104-024-01108-2

Journal of Animal Science and Biotechnology

Table 11 Evaluation score of important shared differential metabolites in four treatments

From: Assessment of the dietary amino acid profiles and the relative biomarkers for amino acid balance in the low-protein diets for broiler chickens

Item	NP vs. LP			LPAB vs. LPAI
Item	VIP	P-value¹	FC²	VIP	P-value¹	FC²
Oxypurinol³	1.522	0.001	0.241	1.987	< 0.001	0.420
Pantothenic acid	1.513	0.002	20.226	2.055	0.001	10.359
D-Octopine	1.529	< 0.001	0.170	1.923	0.003	0.328
Xanthine	1.519	0.003	0.107	1.937	< 0.001	0.348
6-Tuliposide B	1.522	< 0.001	0.188	1.835	< 0.001	0.455
Uridine 5′-monophosphate (UMP)	1.454	< 0.001	8.165	1.800	0.002	2.098
Thiamine	1.352	0.001	0.298	2.028	< 0.001	0.242
N-(4-Hydroxyphenyl)glycine	1.406	0.003	0.202	2.017	< 0.001	0.212
Pyridoxal (Vitamin B₆)	1.406	0.003	0.202	2.017	< 0.001	0.212
5′-Phosphoribosylglycinamide	1.446	0.022	0.154	2.000	0.013	0.083
Gly-His	1.479	0.004	0.042	2.111	0.004	0.029
1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphoserine	1.463	< 0.001	19.560	1.751	0.002	3.283
Chenodeoxycholic acid	1.451	0.007	0.019	1.820	0.032	0.214
Deoxycholic acid	1.451	0.007	0.019	1.820	0.032	0.214
Hyodeoxycholic acid	1.451	0.007	0.019	1.820	0.032	0.214
Isodeoxycholic acid	1.451	0.007	0.019	1.820	0.032	0.214
Ursodeoxycholic acid	1.451	0.007	0.019	1.820	0.032	0.214
Arachidonic acid (AA)	1.356	0.020	0.112	1.827	0.014	0.288
4-Amino-4-deoxychorismate	1.486	< 0.001	0.145	1.922	0.005	0.296
2-Piperidone	1.217	0.030	0.296	1.769	0.015	0.418
D-galacto-Hexodialdose	1.491	0.001	0.085	1.933	0.004	0.096
N-Oleoyl glycine	1.502	0.018	0.009	1.674	0.002	0.065
Linoleoylglycine	1.459	0.009	0.006	1.716	0.006	0.040
1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphoserine	1.448	< 0.001	11.546	1.767	< 0.001	2.929
5-Tetradecynoic acid	1.487	0.003	0.105	2.010	0.014	0.143
Hygric acid	1.265	0.016	0.186	2.026	0.022	0.091
Pipecolic acid	1.265	0.016	0.186	2.026	0.022	0.091
2-Oxo-4-phosphonobutanoate	1.499	0.004	0.133	1.935	0.008	0.280
M345T195	1.532	< 0.001	0.017	1.850	0.042	0.021
Dephospho-CoA	1.405	0.001	29.684	1.859	< 0.001	7.405
M368T281	1.510	0.003	0.053	2.050	0.012	0.097
Pantetheine 4′-phosphate	1.309	0.002	21.895	1.985	0.008	14.229
Eglumegad	1.485	0.003	0.277	1.878	0.004	0.438
N-Arachidonylglycine	1.422	0.012	0.009	1.795	0.008	0.035
N-Acetylmannosamine	1.502	0.001	0.219	1.897	0.005	0.353
Pyridoxamine	1.484	0.001	0.205	1.834	0.001	0.267
Goralatide (acetate)	1.491	0.004	0.056	2.103	0.004	0.090
N-Acetylglucosaminylasparagine	1.524	< 0.001	6.893	1.900	< 0.001	3.925
3-beta-D-Galactosyl-sn-glycerol	1.406	0.007	0.007	1.985	0.015	0.026
M730T215	1.413	0.001	17.590	1.730	0.023	15.166
Acetyl-CoA	1.365	< 0.001	18.480	1.814	0.037	7.012
M374T236	1.478	< 0.001	0.036	2.135	0.002	0.012
Uric acid	1.092	0.029	1.963	0.844	0.107	1.270
Urea	1.270	0.001	2.179	0.135	0.804	1.025

NP Normal CP diet, LP Low-CP diet, LPAB Low-CP amino acid balance diet, LPAI Low-CP amino acid imbalance diet, VIP Variable importance in the projection scores, FC Fold change
¹Volcano plot analysis provides the P-value, which is a combination of the fold change and t-test analyses
²FC= LP relative quantitation/NP relative quantitation and LPAI relative quantitation/LPAB relative quantitation
³All data in the table are expressed as relative quantification (intensity)

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ISSN: 2049-1891

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