Fig. 3

Differential functions of fecal microbiome regarding tryptophan metabolism between healthy and diarrheal weaned piglets. a Functional analysis of top 10 differential gene expression between CON and DIA groups based on P value. b The normalized relative abundance of DNA sequence reads mapping to the pathway of KEGG tryptophan metabolism (map00380). c The phylogenetic distributions of sequences in tryptophan metabolism at genus levels are based on the abundance of TPM assigned to each KO gene. d The cartoon displays the Trp catabolism to kynurenine (Kyn), indole, indole-3-acetic acid (IAA), and IAld and enzymes involved in each pathway. e–g The relative abundance of enzymes involved in the microbial catabolism of tryptophan in healthy and diarrheal piglets. KynB, kynurenine 3-monooxygenase. tnaA, tryptophanase. ALDH, aldehyde dehydrogenase. The results are expressed as the mean ± SEM (n = 10). ^*P < 0.05