Fig. 4

Baicalin regulated gene expression caused by E. coli infection (n = 5). A Scatter plot of expression difference (Fold change > 1.8, P < 0.05). Each dot represents an individual gene. Red dots represent the significantly up-regulated genes, blue dots represent the significantly down-regulated genes, and gray dots represent non-significant differential genes. B Clustering heat map, trend analysis and enriched GO terms for all differential genes in E. coli vs. CON and BL + E. coli vs. E. coli group. C KEGG enrichment analysis of differential genes in E. coli vs. CON and BL + E. coli vs. E. coli group. D Th17 cell differentiation pathways and IL-17 signaling pathway gene expression heatmap. E and F The main network cluster of genes different expression between E. coli and CON (E), and between BL + E. coli and E. coli (F). Each nodes representing a gene, and edges each representing an interaction between two genes. Blue nodes represent genes that are significantly up-regulated, and pink nodes represent genes that are significantly down-regulated