Fig. 4
WGCNA of gene expression modules in response to bta-miR-223 modulation in MAC-T cells. This heatmap depicts the correlations between gene expression modules and the effects of bta-miR-223 modulation under various experimental conditions: KD (knockdown), CKD (control for knockdown), OE (overexpression), and COE (control for overexpression). Each row, represented by a unique colour, corresponds to a distinct gene module. The cells within the heatmap display correlation coefficients; P-values in parentheses indicate the statistical significance of the correlations between each module and the experimental groups (bta-miR-223 modulation). The intensity of the colours—red indicating positive and blue indicating negative correlations. To the left, coloured boxes corresponding to the modules highlight specific biological pathways affected by the treatments, identified through KEGG enrichment analysis. The significance levels of these pathways are indicated by BH-Padj., with significance levels noted (* BH-Padj. < 0.05, ** BH-Padj. < 0.01, *** BH-Padj. < 0.001)