The multifaceted role of ferroptosis in infection and injury and its nutritional regulation in pigs

Table 1 Induction or inhibition of ferroptosis by porcine viruses

Viruses	Effects	Outcomes	Targeted cells	References
PDCoV	Upregulate expression of TFR and LPCAT3; Downregulate expression of ACSL5 and SLC7A11	Activation of ferroptosis inhibits viruse replication	IPEC-J2	[34]
PEDV	Ferroptosis activator (1S,3R)-RSL3 and erastin inhibit System Xc⁻/GPX4 axis and the replication of PEDV	Activation of ferroptosis inhibits viruse replication but does not affect the adhesion, invasion, and release of PEDV	Vero	[35, 36]
SIV	Increase expression of TFR1 and inhibit System Xc⁻/GPX4 axis	Activation of ferroptosis promotes virus replication	A549	[9]
SADS-CoV	Downregulate expression of ACSL4, COX2, and NOX4; Upregulate expression of GPX4, SLC7A11, and FTH1	Inhibition of ferroptosis promotes virus replication	IPI-FX	[37]
ASFV	Do not induce ferroptosis; Brequinar inhibits ASFV replication by activating ferroptosis	Activation of ferroptosis inhibits viruse replication	PAM	[38]

ACSL Acyl-CoA synthetase long chain family member, ASFV African swine fever virus, COX Cyclooxygenase, FTH Ferritin heavy chain, GPX4 Glutathione peroxidase 4, IPI-FX Porcine ileum epithelial cell line, LPCAT3 Lysophosphatidylcholine acyltransferase 3, NOX NADPH oxidase, PAM Porcine alveolar macrophage, PDCoV Porcine deltacoronavirus, PEDV Porcine epidemic diarrhea virus, SADS-CoV Swine acute diarrhea syndrome coronavirus, SIV Swine influenza virus, SLC7A11 Solute carrier family 7 member 11, TFR Transferrin receptor

ISSN: 2049-1891