Table 2 Ferroptosis involved in gastrointestinal system and reproductive system injury of pigs

Gastrointestinal system

 FAC

IPEC-J2 cells

Reduce cell activity and antioxidant capacity, impair intestinal epithelial barrier, and disrupt mitochondrial function due to the activation of ferroptosis

[54]

 DON

Pigs, IPEC-J2 cells

Increase the concentrations of MDA and protein carbonyl in duodenum, jejunum and ileum; Upregulate expression of ferroptotic gene (DMT1) and anti-ferroptotic genes (FTL and FTH1) and downregulate expression of anti-ferroptotic genes (FPN, FSP1 and CISD1) in duodenum

[55]

 PDCoV

IPEC-J2 cells

Upregulate expression of TFR and LPCAT3; Downregulate expression of ACSL5 and SLC7A11;

Activation of ferroptosis inhibits PDCoV replication

[34]

 PEDV

Vero cells

Activation of ferroptosis inhibits PEDV replication

[35, 36]

 SADS-CoV

IPI-FX cells

Downregulate expression of ACSL4, COX2, and NOX4; Upregulate expression of GPX4, SLC7A11, and FTH1; Activation of ferroptosis promotes SADS-CoV replication

[37]

 Diquat

Pigs

Upregulate expression of TFR1 and downregulate expression of GPX4 in jejunum and ileum

[56]

 Irradiation

Göttingen minipigs

Downregulate expression of GPX4 and SLC7A11 in the intestine

[57]

Reproductive system

 ZEN

Female pigs

Upregulate expression of p-P53, P53, and ACSL4 in the uterus

[58]

 Heat stress

Porcine Sertoli cells

Upregulate expression of GPX4, TFR1, and ferritin; Increase level of intracellular ROS

[59]

 Zinc

Porcine testis cells

Downregulate expression of SLC7A11, GPX4, and ferritin; Upregulate TF; Increase the concentration of MDA

[60]