Fig. 6

OCA effectively alleviates the inhibition of the ileal FXR pathway and the upregulation of hepatic CYP8B1 caused by AFB1. A Protein expression levels of ileal FXR and SHP (n = 6). B Levels of FGF19 in the serum of piglets (n = 6). C Relative mRNA expression of hepatic CYP8B1 and CYP7A1 (n = 6). D Concentration of TC, TG and FFA in the colonic contents (n = 6). Statistical analysis: one-way ANOVA and Tukey’s post-test for the comparison of four groups (***P < 0.001; **P < 0.01; *P < 0.05)