Fig. 7

Cyp8b1-KO mice exhibit reduced absorption of AFB1 compared to WT mice. A Experimental design. B Levels of AST, ALT, TBA in the serum of mice (n = 6). C Representative images of liver sections stained with H&E. D TEM of liver sections. E Relative mRNA expression of hepatic Cyp8b1 and Cyp7a1 (n = 6). F AFB1 residues in the serum, contents of each intestinal segment and feces of mice (n = 6). Statistical analysis: unpaired two-tailed Student’s t-test for the comparison of two groups, one-way ANOVA and Tukey’s post-test for the comparison of four groups (^****P < 0.0001; ^***P < 0.001; ^**P < 0.01; ^*P < 0.05)