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Fig. 8 | Journal of Animal Science and Biotechnology

Fig. 8

From: Gut microbiota-mediated bile acid transformations regulate the transport of aflatoxin B1 from the intestine to the liver in piglets

Fig. 8

The proposed mechanism by which aflatoxin affects its toxicity via the gut microbiota-bile acid axis. AFB1 inhibits the BSH activity of ileal microbiota and upregulates hepatic CYP8B1 expression by suppressing the ileal FXR pathway, then the increased expression of CYP8B1 results in a higher proportion of 12α-OH BAs in bile acids, which facilitates the absorption of AFB1 in animals

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Journal of Animal Science and Biotechnology

ISSN: 2049-1891