Fig. 5

Hypoxia-induced transcriptomic changes in genes associated with lactation. A Milk fat synthesis related genes. The genes were classified into de novo synthesis of FA (ACSS2, Acyl-CoA synthetase short-chain family member 2; FASN, Fatty acid synthase; FADS6, Fatty acid desaturase 6; GK, Glucokinase), FA uptake from blood (ACACA, Acetyl-CoA carboxylase alpha; CD36, Cluster of differentiation 36; SLC27A6, Solute carrier family 27 member 6; SLC27A1, Solute carrier family 27 member 1; ACSL1, Acyl-CoA synthetase long-chain family member 1), FA transport and desaturation (FABP3, Fatty acid binding protein 3), TAG synthesis (DGAT1, Diacylglycerol O-acyltransferase 1; LPIN1, Lipin 1; GPAM, Glycerol-3-phosphate acyltransferase mitochondrial), Lipid droplet secretion (PLIN2, Perilipin 2; XDH, Xanthine dehydrogenase; ADFP, Adipose differentiation-related protein), and FA elongation (ELOVL4, Elongation of very long chain fatty acids protein 4). B Milk protein synthesis related genes. The genes were classified into Casein genes (CSN3, Casein kappa), AA Transporter (SLC7A5, Solute carrier family 7 member 5; SLC7A1, Solute carrier family 7 member 1; SLC1A1, Solute carrier family 1 member 1; SLC1A5, Solute carrier family 1 member 5; SLC3A2, Solute carrier family 3 member 2; SLC36A1, Solute carrier family 36 member 1), Translation elongation (EEE1A1, Eukaryotic translation elongation factor 1 alpha 1; EEF2, Eukaryotic translation elongation factor 2), Ribosomal function (PRL8, Ribosomal protein L8; PRL4, Ribosomal protein L4; PRL22, Ribosomal protein L22; PRL23, Ribosomal protein L23; PRL35, Ribosomal protein L35; PR36KB1, Ribosomal protein S6 kinase B1), Translation initiation (EIF4E, Eukaryotic translation initiation factor 4E; EIF4EBP1, Eukaryotic translation initiation factor 4E binding protein 1). C Lactose synthesis related genes. The genes were classified into Glucose uptake (SLC2A1, Solute carrier family 2 member 1; SLC2A2, Solute carrier family 2 member 2; SLC2A3, Solute carrier family 2 member 2; SLC2A8, Solute carrier family 2 member 8; SLC2A12, Solute carrier family 2 member 12), Lactose synthase activity (B4GLAT1, Beta-1,4-galactosyltransferase 1), UDP-galactose transport (SLC35A2, Solute carrier family 35 member A2; UGP2, UDP-glucose pyrophosphorylase 2; PGM1, Phosphoglucomutase 1), Lactose precursor production (HK1, Hexokinase 1; HK2, Hexokinase 1; GALE, UDP-galactose-4-epimerase; PCK2, Phosphoenolpyruvate carboxykinase 2; ENO1, Alpha-enolase; G6PD, Glucose-6-phosphate dehydrogenase). D Signal transduction related genes. JAK2, Janus kinase 2; STAT5B, Signal transducer and activator of transcription; PRLR, Prolactin receptor; AKT1, AKT serine/threonine kinase 1; AKT3, AKT serine/threonine kinase 3; MTOR, Mechanistic target of rapamycin; GSK3A, Glycogen synthase kinase 3 alpha; INSR, Insulin receptor; IRS1, Insulin receptor substrate 1; MAPK14, Mitogen-activated protein kinase 14; PDPK1, Phosphoinositide-dependent protein kinase 1; PIK3C2A, Phosphoinositide-3-kinase catalytic subunit type 2 alpha; STK11, Serine/threonine kinase 11