Fig. 6

Hypoxia-induced transcriptomic changes in genes associated with energy metabolism. A Glycolysis. HK1, Hexokinase 1; HK2, Hexokinase 2; GP1, Glycogen phosphorylase 1; PFKB1, 6-phosphofructokinase 1; PFKB2, 6-Phosphofructokinase 2; PFKB3, 6-Phosphofructokinase 3; PFKB4, 6-Phosphofructokinase 4; PFKL, Phosphofructokinase L; PFKM, Phosphofructokinase M; ALDOB, Aldolase B; ALDOA, Aldolase B; TPI1, Triosephosphate isomerase 1; GAPDH, Glyceraldehyde-3-phosphate dehydrogenase; PGK1, Phosphoglycerate kinase 1; PGM1, Phosphoglucomutase 1; ENO1, Alpha-enolase; ENO2, Beta-enolase; ENO3, Gamma-enolase; PKM, Pyruvate kinase M1/M2; PKLR, Pyruvate kinase L/R; LDHA, Lactate dehydrogenase A; LDHB, Lactate dehydrogenase B; LDHC, Lactate dehydrogenase C; LDHD, Lactate dehydrogenase D. B TCA cycle. CS, Citrate synthase; ACO2, Aconitase 2; IDH3A, Isocitrate dehydrogenase 3 alpha; IDH3G, Isocitrate dehydrogenase 3 gamma; IDH3B, Isocitrate dehydrogenase 3 beta; OGDH, Oxoglutarate dehydrogenase; SUCLG2, Succinate-CoA ligase GDP-forming beta subunit; SUCLA2, Succinate-CoA ligase alpha subunit; SUCLG1, Succinate-CoA ligase beta subunit; SDHA, Succinate dehydrogenase complex flavoprotein subunit A; SDHB, Succinate dehydrogenase complex iron-sulfur subunit B; SDHC, Succinate dehydrogenase complex subunit C; SDHD, Succinate dehydrogenase complex subunit D; FH, Fumarate hydratase; MDH2, Malate dehydrogenase 2; MDH1, Malate dehydrogenase 2. C Cytosol-Mitochondria transport The genes were classified into TOM complex (TOMM20, Translocase of outer mitochondrial membrane 20; TOMM40, Translocase of outer mitochondrial membrane 44; TOMM22, Translocase of outer mitochondrial membrane 22; TOMM70, Translocase of outer mitochondrial membrane 70; TOMM5, Translocase of outer mitochondrial membrane 5; TOMM6, Translocase of outer mitochondrial membrane 6), TIM complex (TIMM23, Translocase of inner mitochondrial membrane 23; TIMM44, Translocase of inner mitochondrial membrane 44), HSP (HSPA9, Heat shock 70 kDa protein 9). D Nuclear-encoded ETC genes. The genes were classified into Complex I (NDUFV1, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 1; NDUFV2, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 2; NDUFS1, NADH dehydrogenase [ubiquinone] 1 beta subcomplex, 1; NDUFS2, NADH dehydrogenase [ubiquinone] 1 beta subcomplex, 2; NDUFS3, NADH dehydrogenase [ubiquinone] 1 beta subcomplex, 3; NDUFA1, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 1; NDUFA2, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 2; NDUFA3, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex, 3), Complex II (SDHA, Succinate dehydrogenase complex flavoprotein subunit A; SDHB, Succinate dehydrogenase complex iron-sulfur subunit B; SDHC, Succinate dehydrogenase complex subunit C; SDHD, Succinate dehydrogenase complex subunit D), Complex III (UQCRC1, Ubiquinol-cytochrome c reductase complex core protein 1; UQCRFS1, Ubiquinol-cytochrome c reductase complex supernumerary subunit 1), Complex IV (COX4I1, Cytochrome c oxidase subunit 4 isoform 1; COX5A, Cytochrome c oxidase subunit 5A; COX5B, Cytochrome c oxidase subunit 5B; COX6A1, Cytochrome c oxidase subunit 6A1; COX6B1, Cytochrome c oxidase subunit 6B1; COX7A2, Cytochrome c oxidase subunit 7A2; COX7B, Cytochrome c oxidase subunit 7B; COX8B, Cytochrome c oxidase subunit 8B), ATP synthase (ATP5F1A, ATP synthase F1 subunit alpha; ATP5F1B, ATP synthase F1 subunit beta; ATP5F1C, ATP synthase F1 subunit gamma; ATP5F1D, ATP synthase F1 subunit delta; ATP5F1E, ATP synthase F1 subunit epsilon; ATP5ME, ATP synthase mitochondrial E; ATP5MF, ATP synthase mitochondrial; ATP5MG, ATP synthase mitochondrial; ATP5PB, ATP synthase F0 subunit b; ATP5PD, ATP synthase F0 subunit d; ATP5PO, ATP synthase F0 subunit o; ATPAF1, ATP synthase assembly factor 1; ATPAF2, ATP synthase assembly factor 2). E Mitophagy & Autophagy. PINK1, PTEN-induced kinase 1; PRKN, Parkin RBR E3 ubiquitin protein ligase; FUNDC1, FUN14 domain containing 1; BNIP3, BCL2/adenovirus E1B 19kDa interacting protein 3; BNIP3L, BCL2/adenovirus E1B 19kDa interacting protein 3-like; UCP2, Uncoupling protein 2; PRKAA2, Protein kinase AMP-activated catalytic subunit alpha 2; SIRT1, Sirtuin 1; ULK1, Unc-51 like autophagy activating kinase 1; OPA1, Mitochondrial dynamin-like GTPase. F Positive regulation of reactive oxygen species production. NOX1, NADPH oxidase 1; CYBB, Cytochrome b-245 beta chain; NCF1, Neutrophil cytosolic factor 1; NOXO1, NADPH oxidase organizer 1; NOX5, NADPH oxidase 5; NOS2, Nitric oxide synthase 2; NOS3, Nitric oxide synthase 3. G Negative regulation of reactive oxygen species production. SOD1, Superoxide dismutase 1; SOD2, Superoxide dismutase 2; SOD3, Superoxide dismutase 3; GPX1, Glutathione peroxidase 1; GPX4, Glutathione peroxidase 4