Fig. 8

Interactions between testicular cells in mice after GenX exposure. A Bar plot showing the number and strength of cell–cell interactions in mouse testes after GenX exposure compared to control. The Control label refers to the interaction between testicular cells of the control mice, and the GenX label refers to the interaction between testicular cells of the mice after GenX exposure. B Network plot for the differential number of interactions or interaction strengths in the communication network between different mouse testicular cell types after GenX exposure compared to control. C Outgoing and incoming communication probabilities and number of interactions in different cell types of mouse testis. D and E Heatmap showing the relative strength of outgoing (D) and incoming (E) signals in each testicular cell type after GenX exposure compared with the control group. The bar plot above showing the relative strength of overall signals in each testicular cell type. F Bar plot showing the overall strength of each signaling pathway after GenX exposure compared with the control group. G Dot plot showing outgoing signals from germ cells emitted to somatic cells. Dot color reflects communication probabilities and dot size represents computed P-values. Empty space means the communication probability is zero. P-values are computed from one-sided permutation test. H Dot plot showing outgoing signals from somatic cells emitted to germ cells