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Fig. 6 | Journal of Animal Science and Biotechnology

Fig. 6

From: ROS-DRP1-mediated excessive mitochondrial fission and autophagic flux inhibition contribute to heat stress-induced apoptosis in goat Sertoli cells

Fig. 6

The DRP1 inhibitor Mdivi-1 ameliorates mitochondrial dysfunction. A SCs were treated with different concentrations of Mdivi-1, and cell viability was assessed using the CCK-8 assay. B Effects of Mdivi-1 pretreatment on mitochondrial morphology in SCs. C Morphological factors (aspect ratio and shape factor) were evaluated after Mdivi-1 pretreatment. D and E Representative images and quantitative analysis of mitochondrial ROS after Mdivi-1 pretreatment. F ATP content were measured in SCs following Mdivi-1 pretreatment. G and H Representative images and analysis of mitochondrial membrane potential (ΔΨm) after Mdivi-1 pretreatment. *P < 0.05, **P < 0.01 vs. control; #P < 0.05 vs. HS

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Journal of Animal Science and Biotechnology

ISSN: 2049-1891