Fig. 5

Sodium lactate disrupted the mammary gland circadian transcriptome. a MAC-T cells were synchronized with dexamethasone (100 nmol/L, 30 min) and collected at indicated timepoints (n = 3/timepoint/group). ZT Zeitgeber time. b eJTK_Cycle analyses following RNA-seq every 4 h across 24 h identified transcripts that lost, gained, or phase-shift > 4 h oscillations following sodium lactate (FDR-adjusted P-value < 0.1 and > 0.9 for cycling and non-cycling genes, respectively). c Heatmap of lost, gained, or phase-shift transcripts between Con and 15LNa group. d Heatmap of lost, gained, or phase-shift transcripts between Con and 30LNa group. e KEGG ontology terms are shown for gain genes overlap between 15 and 30LNa group. f KEGG ontology terms are shown for loss genes overlap between 15 and 30LNa group. g KEGG ontology terms are shown for phase-shift genes overlap between 15 and 30LNa group