Fig. 4

Dynamic changes of PBMC transcriptome at different developmental stages. A Upset diagram of porcine PBMC differentially expressed genes between 1-month-old (1M), 4-month-old (4M) and 7-month-old (7M). B overlap map of 1M and 4M DEG, 1M and 7M DEG and darkgrey module genes. C Heatmap of expression of seven immune candidate genes in six immune tissues. D Epigenetic modification peaks (ATAC, H3K4me1, H3K4me3, H3K27ac, H3K27me3) in the promoter regions of MX1 and MX2 genes. E The gene expression of IFI44, MX1, and MX2 in three different developmental stages. F Immune pathway activity scores of PBMC samples from different age groups (1M, 4M and 7M) G Heatmap of GO enrichment analysis for core genes in up clusters and down clusters